Fahrenbach Group


Origins of Life Chemistry Research

2024

72. A. C. Fahrenbach, H. J. Cleaves II. Prebiotic Chemistry, 2024, Oxford Chemistry Primers, Oxford University Press.

71. L. K. Marshall, A. C. Fahrenbach, P. Thordarson. RNA-Binding Peptides Inspired by the RNA Recognition Motif. ACS Chem. Biol. 2024, https://doi.org/10.1021/acschembio.3c00694.

2023

70. Z. Peng, Z. R. Adam, A. C. Fahrenbach, B. Kaçar. Assessment of Stoichiometric Autocatalysis across Element Groups. J. Am. Chem. Soc. 2023, 145, 22483.
(Based on preprint, see Publication 67 in 2023)
Got the cover for the issue! 
Figure 1

69. R. Yi, M. Mojica, A. C. Fahrenbach, H. J. Cleaves II, R. Krishnamurthy, C. L. Liotta. Carbonyl Migration in Uronates Affords a Potential Prebiotic Pathway for Pentose Production. J. Am. Chem Soc. Au 2023 3, 2522.
Got the Cover for the Issue!

68. Q. P. Tran, R. Yi, A. C. Fahrenbach. Towards a Prebiotic Chemoton – Nucleotide Precursor Synthesis Driven by the Autocatalytic Formose Reaction. Chem. Sci. 2023, 14, 9589.

67. Z. Peng, B. Kaçar, A. C. Fahrenbach, Z. R. Adam. An Assessment of Stoichiometric Autocatalysis Across Element Groups. ChemRxiv 2023, https://doi.org/10.26434/chemrxiv-2023-zhktd

66. Simone I. S. Hendrikse, Nevena Todorova, Hamid Soleimaninejad, Patrick Charchar, Marc-Antoine Sani, Karrar Al Taief, Jonathan F. Berengut, Shelley F. J. Wickham, Sally L. Gras, Albert C. Fahrenbach, Pall Thordarson, and Amanda V. Ellis. Exploring Artificial Nucleic Acid Mimicking Peptide Nanofibers. Chem. Mater. 2023, 35, 4355.

Abstract Image

65. Ruiqin Yi, Tony Z. Jia, Markus Meringer, Luke K. Marshall, Chen Chen, Shawn Erin McGlynn, Albert C. Fahrenbach. H. James Cleaves, II. Alternating Co-Synthesis of Glycol Nucleic Acid (GNA) Monomers with Dicarboxylic Acids via Drying. Chem. Commun. 2023, 59, 6865.
Highlighted by Phys.org 

Graphical abstract: Alternating co-synthesis of glycol nucleic acid (GNA) monomers with dicarboxylic acids via drying

2022

64. H. J. Cleaves, A. C. Fahrenbach. Topic 2: Emergence of Life on Earth in Biological Science by J. Scott, et al. 2022, Oxford University Press.

63. A. Saha, R. Yi; A. C. Fahrenbach, A. Wang, T. Z. Jia. A Physicochemical Consideration of Prebiotic Microenvironments for Self-Assembly and Prebiotic Chemistry. Life 202212, 1595.

2021

62. Z. R. Adam, A. C. Fahrenbach, S. M. Jacobson, B. Kacar, D. Yu. Zubarev. Radiolysis Generates a Complex Organosynthetic Chemical Network. Sci. Rep. 2021, 11, Article Number 1743.

(Based on preprint, see Publication 54 in 2019)

2020

61.  R. Yi, A. C. Fahrenbach, Y. Hongo. Radiolytically Driven Chemical Evolution 2020. J. Geography (Chigaku Zasshi), 2020, 129, 837.

60. Q. P. Tran, Z. R. Adam, A. C. Fahrenbach. Prebiotic Reaction Networks in Water. Life 2020, 10, 352.

59. A. C. Fahrenbach, Q. P. Tran. Prebiotic Metabolism Gets a Boost. Nature Chem. News&Views. 2020, 12, 982.

 

58. R. W. J. Lim, A. C. Fahrenbach. Radicals in Prebiotic Chemistry. Pure Appl. Chem. 2020, 117, 13267.

 

57. R. YiQ. P. TranS. AliI. Yoda, Z. R. AdamH. J. Cleaves II, A. C. Fahrenbach. A Continuous Reaction Network that Produces RNA precursors. Proc. Natl. Acad. Sci. USA 2020,

56. Z. R. Todd, A. C. Fahrenbach, S. Ranjan, C. J. Magnani, J. W. Szostak, D. D. Sasselov. Ultraviolet-Driven Deamination of Cytidine Ribonucleotides Under Planetary Conditions. Astrobiol. 2020, 20, 878.

2019

55. Jiao, G.Wu, Y. Zhang, L. Shen, Y. Lei, C.-Y. Wang, A. C. Fahrenbach, H. Li. Self‐Assembly in Water with N‐Substituted Imines. Angew. Chem. Int. Ed. 2020, 59, 2.

54.  Z. Adam, A. C. Fahrenbach, S. M. Jacobson, B. Kacar, D. Yu. Zubarev. Radiolysis Generates a Complex Organosynthetic Chemical Network. ChemRxiv Preprint 2019, doi.org/10.26434/chemrxiv.10148684.v1 

2018

53.  R. Yi, Y. Hongo, I. Yoda, Z. R. Adam, A. C. Fahrenbach. Radiolytic Synthesis of Cyanogen Chloride, Cyanamide and Simple Sugar Precursors. ChemistrySelect 2018, 3, 10169.

52. Z. R. Adam, A. C. Fahrenbach, B. Kacar, M. Aono. Prebiotic Geochemical Automata at the Intersection of Radiolytic Chemistry, Physical Complexity, and Systems Biology. Complexity 2018, Article ID 9376183.

51.  Z. Todd, A. C. Fahrenbach, C. Magnani, S. Ranjan, A. Björkbom, D. D. Sasselov, J. W. Szostak. Solvated-Electron Production Using Cyanocuprates is Compatible with the UV-Environment on a Hadean-Archaean Earth. Chem. Commun. 2018, 54, 1121.

50.  R. Yi, Y. Hongo, A. C. Fahrenbach. Synthesis of Imidazole-Activated Ribonucleotides Using Cyanogen Chloride. Chem. Commun. 2018, 54, 511

49.  Z. R. Adam, Y. Hongo, H. J. Cleaves II, R. Yi, A. C. Fahrenbach, I. Yoda, M. Aono. Estimating the Capacity for Production of Formamide by Radioactive Minerals on the Prebiotic Earth. Sci. Rep. 2018, 8, 265. 

48.  C. P. Tam, L. Zhou, A. C. Fahrenbach, W. Zhang, T, Walton, J. W. Szostak. Synthesis of a Nonhydrolyzable Nucleotide Phosphoroimidazolide Analogue that Catalyzes Nonenzymatic RNA Primer Extension. J. Am. Chem. Soc. 2018, 140, 783.

2017

47.  W. Zhang, C. P. Tam, T. Walton, A. C. Fahrenbach, G. Birraneg, J. W. Szostak. Insight into the Mechanism of Nonenzymatic RNA Primer Extension from the Structure of an RNA-GpppG Complex. Proc. Natl. Acad. Sci. USA 2017, 114, 7659.

46.  A. C. Fahrenbach, C. Giurgiu, C. P. Tam, L. Li, Y. Hongo, M. Aono, J. W. Szostak. Common and Potentially Prebiotic Origin for Precursors of Nucleotide Synthesis and Activation. J. Am. Chem. Soc. 2017, 139, 8780 († Equal Contributions).

45.  C. P. Tam, A. C. Fahrenbach, A. Björkbom, N. Prywes, E. C. Izgu, J. W. Szostak. Downstream Oligonucleotides Strongly Enhance The Affinity of GMP to RNA Primer-Template Complexes. J. Am. Chem. Soc. 2017, 139, 571 († Equal Contributions).

2016

44.  C. Cheng, T. Cheng, H. Xiao, M. D. Krzyaniak, Y. Wang, P. R. McGonigal, M. Frasconi, J. C Barnes, A. C. Fahrenbach, M. R. Wasielewski, W. A. Goddard III, J. F. Stoddart. Influence of Constitution and Charge on Radical Pairing Interactions in Trisradical Tricationic Complexes. J. Am. Chem. Soc. 2016, 138, 8288.

43.  K. J. Hartlieb, W.-G. Liu, A. C. Fahrenbach, A. K. Blackburn, M. Frasconi, N. Hafezi, S. K. Dey, A. A. Sarjeant, C. L. Stern, W. A. Goddard III, J. F. Stoddart. Quantum Mechanical and Experimental Validation that Cyclobis(paraquat-p-phenylene) Forms a 1:1 Inclusion Complex with Tetrathiafulvalene. Chem. Eur. J. 2016, 22, 2736.

2015

42.  A. T. Larsen, A. C. Fahrenbach, J. Sheng, J. Pian, J. W. Szostak. Thermodynamic Insights into 2-Thiouridine-Enhanced RNA Hybridization. Nucleic Acids Res. 2015, 43, 7675.

41.  E. C. Izgu, A. C. Fahrenbach, N. Zhang, L. Li, W. Zhang, A. T. Larsen, J. C. Blain, J. W. Szostak. Uncovering the Thermodynamics of Monomer Binding for RNA Replication. J. Am. Chem. Soc. 2015, 137, 6373 († Equal Contributions).

40.  A. C. Fahrenbach. Template-Directed Nonenzymatic Oligonucleotide Synthesis: Lessons from Synthetic Chemistry. Pure Appl. Chem. 2015, 87, 205.

2014

39.  L. S. Witus, K. J. Hartlieb, Y. Wang, A. Prokofjevs, M. Frasconi, J. C. Barnes, E. J. Dale, A. C. Fahrenbach, J. F. Stoddart. Relative Contractile Motion of the Rings in a Switchable Palindromic [3]Rotaxane in Aqueous Solution Driven by Radical-Pairing Interactions. Org. Biomol. Chem. 2014, 12, 6089.

38.  K. Nchimi-Nono, P. Dalvand, K. Wadhwa, S. Nuryyeva, S. Alneyadi, T. Prakasam, A. C. Fahrenbach, J.-C. Olsen, Z. Asfari, C. Platas-Iglesias, M. Elhabiri, A. Trabolsi. Radical-Cation Dimerization Overwhelms Inclusion in [n]Pseudorotaxanes. Chem. Eur. J. 2014, 20, 7334.

37.  A. C. Fahrenbach, C. J. Bruns, H. Li, A. Trabolsi, A. Coskun, J. F. Stoddart. Ground-State Kinetics of Bistable Redox-Active Donor–Acceptor Mechanically Interlocked Molecules. Acc. Chem. Res. 2014, 47, 482.

2013

36.  H. Li, C. Cheng, P. R. McGonigal, A. C. Fahrenbach, M. Frasconi, W.-G. Liu , Z. Zhu, Y. Zhao, C. Ke, J. Lei, R. M. Young, S. M. Dyar, D. T. Co, Y.-W. Yang, Y. Y. Botros, W. A. Goddard III, M. R. Wasielewski, R. D. Astumian, J. F. Stoddart. Relative Unidirectional Translation in an Artificial Molecular Assembly Fueled by Light. J. Am. Chem. Soc. 2013, 135, 18609.

35.  Z. Liu, M. Frasconi, J. Lei, Z. J. Brown, Z. Zhu, D. Cao, J. Iehl, G. Liu, A. C. Fahrenbach, O. K. Farha, J. T. Hupp, C. A. Mirkin, Y. Y. Botros, J. F. Stoddart. Selective Isolation of Gold Facilitated by Second-Sphere Coordination by α-Cyclodextrin. Nature Commun. 2013, 4, Article 1855.

Highlighted in over 500 news outlets including C&E News, Chemistry World and Popular Science.

34.  J. C. Barnes, A. C. Fahrenbach, D. Cao, S. M. Dyar, M. Frasconi, M. A. Giesener, D. Benítez, E. Tkatchouk, O. Chernyashevskyy, W. H. Shin, H. Li, S. Sampath, C. L. Stern, A. A. Sarjeant, K. J. Hartlieb, Z. Liu, R. Carmieli, Y. Y. Botros, J. W. Choi, A. M. Z. Slawin, J. B. Ketterson, M. R. Wasielewski, W. A. Goddard III, J. F. Stoddart. A Radically Configurable Six-State Compound. Science 2013, 339, 429.

Highlighted in Nature Chemistry News and Views and Science.
B. Amabilino. Molecular electronics: Highly charged. Nature Chem. March 2013.
Benniston. Corralling Positively Charged Molecular Radicals. Science January 2013.

33.  A. C. Fahrenbach, S. C. Warren, J. T. Incorvati, A.-J. Avestro, J. C. Barnes, J. F. Stoddart, B. A. Grzybowski. Organic Switches for Surfaces and Devices. Adv. Mater. 2013, 3, 331.

32.  K. Wadhwa, S. Nuryyeva, A. C. Fahrenbach, M. Elhabiri, C. Platas-Iglesias, A. Trabolsi. Intramolecular Redox-Induced Dimerization in a Viologen Dendrimer. J. Mater. Chem. C. 2013, 1, 2302. Inside Cover.

31.  H. Li, Z. Zhu, A. C. Fahrenbach, B. M. Savoie, C. Ke, J. C. Barnes, J. Lei, Y.-L. Zhao, L. M. Lilley, T. J. Marks, M. A. Ratner, J. F. Stoddart. Mechanical Bond-Induced Radical Stabilization. J. Am. Chem. Soc. 2013, 135, 456.

 

30.  A. N. Basuray, H.-P. Jacquot de Rouville, K. J. Hartlieb, A. C. Fahrenbach, J. F. Stoddart. Beyond Perylene Diimides – Diazaperopyrenium Dications as Chameleonic Nanoscale Building Blocks. Chem. Asian J. 2013, 8, 524.

2012

29.  A. C. Fahrenbach, S. Sampath, D. J. Late, S. L. Kleinman, N. Valley, J. C. Barnes, K. J. Hartlieb, Z. Liu, V. P. Dravid, G. C. Schatz, R. P. Van Duyne, J. F. Stoddart. A Semiconducting Organic Radical Cationic Host-Guest Complex. ACS Nano 2012, 6, 9964.

28.  C. Wang, S. Dyar, D. Cao, A. C. Fahrenbach, N. Horwitz, M. Colvin, R. Carmieli, C. Stern, S. Dey, M. Wasielewski, J. F. Stoddart. Tetrathiafulvalene Hetero Radical Cation Dimerization in a Redox-Active [2]Catenane. J. Am. Chem. Soc. 2012, 134, 19136.

27.  A. C. Fahrenbach, Z. Zhu, D. Cao, W.-G. Liu, H. Li, S. K. Dey, S. Basu, A. Trabolsi, W. A. Goddard III, J. F. Stoddart. Radically Enhanced Molecular Switches. J. Am. Chem. Soc. 2012, 134, 16275.

Highlighted in Nature Middle East.  H. Maroon. Flash Device Breaks the Law. November 2012.

26.  C. Wang, D. Cao, A. C. Fahrenbach, S. Grunder, S. K. Dey, A. A. Sarjeant, J. Fraser Stoddart. The Effects of Conformation on the Noncovalent Bonding Interactions in a Bistable Donor-Acceptor [3]Catenane. Chem. Commun. 2012, 48, 9245.

25.  A. C. Fahrenbach, K. J. Hartlieb, C.-H. Sue, C. J. Bruns, G. Barin, S. Basu, M. A. Olson, Y. Y. Botros, A. Bagabas, N. H. Khdary and J. Fraser Stoddart. Rapid Thermally Assisted Donor-Acceptor Catenation. Chem. Commun. 2012, 48, 9141.

24.  A. N. Basuray, H.-P. Jacquot de Rouville, M. W. Ambriogio, A.-J. Avestro, N. L. Strutt, K. J. Hartlieb, C. J. Bruns, S. T. Schneebeli, A. C. Fahrenbach, J. F. Stoddart. The Chameleonic Nature of Diazaperopyrenium Recognition Processes. Angew. Chem. Int. Ed. 2012, 48, 9245.

23.  A. S. Tayi, A. K. Shveyd, C.-H. Sue, J. M. Szarko, B. Rolczynski, Dennis Cao, T. J. Kennedy, A. A. Sarjeant, C. L. Stern, W. F. Paxton, W. Wu, S. K. Dey, A. C. Fahrenbach, J. R. Guest, H. Mohseni, L. X. Chen, K. L. Wang, J. F. Stoddart, S. I. Stupp. Room-Temperature Ferroelectricity in Supramolecular Networks of Charge-Transfer Complexes. Nature 2012, 488, 485.

22.  Z. Zhu, A. C. Fahrenbach, H. Li, J. C. Barnes, Z. Liu, S. M. Dyar, H. Zhang, J. Lei, R. Carmielli, A. A. Sarjeant, C. L. Stern, M. R. Wasielewski, J. F. Stoddart. Controlling Switching in Bistable [2]Catenanes by Combining Donor-Acceptor and Radical-Radical Interactions. J. Am. Chem. Soc. 2012, 134, 11709.

21.  J. C. Barnes, A. C. Fahrenbach, S. M. Dyar, M. Frasconi, M. A. Giesener, Z. Zhu, Z. Liu, K. J. Hartlieb, R. Carmieli, M. R. Wasielewski, J. F. Stoddart. Mechanically-Induced Intramolecular Electron Transfer in a Mixed-Valence Molecular Shuttle. Proc. Natl. Acad. Sci. USA, 2012, 109, 11446.

Front Cover of Special Electrochemistry Issue.

20.  A. C. Fahrenbach, C. J. Bruns, D. Cao, J. F. Stoddart. Ground-State Thermodynamics of Redox-Active Bistable Donor-Acceptor Mechanically Interlocked Molecules. Acc. Chem. Res. 2012, 45, 1581.

19.  C. Wang, D. Cao, A. C. Fahrenbach, L. Fang, M. A. Olson, D. C. Friedman, S. Basu, S. K. Dey, Y. Y. Botros, J. F. Stoddart. Solvent-Dependent Ground-State Distributions in a Donor-Acceptor Redox-Active Bistable [2]Catenane. J. Phys. Org. Chem. 2012, 25, 544.

18.  A. C. Fahrenbach, J. C. Barnes, D. A. Lanfranchi, H. Li, A. Coskun, J. J. Gassensmith, Z. Liu, D. Benítez, A. Trabolsi, W. A. Goddard, M. Elhabiri, J. F. Stoddart. Solution-Phase Mechanistic Study and Solid-State Structure of a Tris(bipyridinium radical cation) Inclusion Complex. J. Am. Chem. Soc. 2012, 134, 3061.

2011

17.  A. C. Fahrenbach, J. C. Barnes, H. Li, D. Benítez, A. N. Basuray, L. Fang, C.-H. Sue, G. Barin, S. K. Dey, W. A. Goddard III, J. F. Stoddart. Measurement of the Ground-State Distributions in Bistable Mechanically Interlocked Molecules Using Slow Scan Rate Cyclic Voltammetry. Proc. Natl. Acad. Sci. USA 2011, 108, 20416.

16.  A. C. Fahrenbach, J. F. Stoddart. Reactions under the Click Chemistry Philosophy Employed in Supramolecular and Mechanostereochemical Systems. Chem. Asian J. 2011, 6, 2660.

Front Cover

15.  J.-C. Olsen, A. C. Fahrenbach, A. Trabolsi, D. C. Friedman, S. K. Dey, C. M. Gothard, A. K. Shveyd, T. B. Gasa, J. M. Spruell, M. A. Olson, C. Wang, H.-P. Jacquot de Rouville, Y. Y. Botros, J. F. Stoddart. A Neutral Redox Switchable [2]Rotaxane. Org. Biomol. Chem. 2011, 9, 7126.

14.  H. Li, A. C. Fahrenbach, A. Coskun, Z. Zhu, G. Barin,Y.-L. Zhao, Y. Y. Botros, J.-P. Sauvage, J. F. Stoddart. A Light-Stimulated Molecular Switch Driven by Radical-Radical Interactions in Water. Angew. Chem. Int. Ed. 2011, 50, 6782. 

Angewandte Chemie Very Important Paper, Inside Cover.

13.  S. K. Dey, A. Coskun, A. C. Fahrenbach, G. Barin, A. N. Basuray, A. Trabolsi, Y. Y. Botros, J. F. Stoddart. A Redox-Active Reverse Donor-Acceptor Bistable [2]Rotaxane. Chem Sci. 2011, 2, 1046.

12.  A. Coskun, J. M. Spruell, G. Barin, A. C. Fahrenbach, R. S. Forgan, M. T. Colvin, R. Carmieli, D. Benítez, E. Tkatchouk, D. C. Friedman, A. A. Sarjeant, M. R. Wasielewski, W. A. Goddard III, J. F. Stoddart. Mechanically Stabilized Tetrathiafulvalene Radical Dimers. J. Am. Chem. Soc. 2011, 133, 4538.

Highlighted in Nature Chemistry News and Views.
Hadlington. Radical Dimers Held Together in Molecular Flask. March 2011.

11.  H. Li, Y. Zhao, A. C. Fahrenbach, S.-Y. Kim, W. F. Paxton, J. F. Stoddart. Degenerate [2]Rotaxanes with Electrostatic Barriers. Org. Biomol. Chem. 2011, 9, 2240. Hot Paper.

10.  L. Fang, S. Basu, C.-H. Sue, A. C. Fahrenbach, J. F. Stoddart. Syntheses and Dynamics of Donor-Acceptor [2]Catenanes in Water. J. Am. Chem. Soc. 2011, 133, 396.

9.  L. Fang, C. Wang, A. C. Fahrenbach, A. Trabolsi, Y. Y. Botros, J. F. Stoddart. Dual Stimulus Switching of a [2]Catenane in Water. Angew. Chem. Int. Ed. 2011, 50, 1805.

8.  M. Hmadeh, A. C. Fahrenbach, S. Basu, A. Trabolsi, D. Benítez, H. Li, A.-M. Albrecht-Gary, M. Elhabiri, J. F. Stoddart.. Electrostatic Barriers in Rotaxanes and Pseudorotaxanes. Chem. Eur. J. 2011, 17, 6076 († Equal Contributions).

7.  S. Basu, A. Coskun, D. C. Friedman, M. A. Olson, D. Benítez, E. Tkatchouk, G. Barin, J. Yang, A. C. Fahrenbach, W. A. Goddard III, J. F. Stoddart. Donor-Acceptor Oligorotaxanes Made to Order. Chem. Eur. J. 2011, 17, 2107.

2010

6.  J. M. Spruell, A. Coskun, D. C. Friedman, R. S. Forgan, A. A. Sarjeant, A. Trabolsi, A. C. Fahrenbach, et al. Highly Stable TTF Radical Dimers in [3]Catenanes. Nature Chem. 2010, 2, 870.

5.  H. Li, A. C. Fahrenbach, S. K. Dey, S. Basu, A. Trabolsi, Z. Zhu, Y. Y. Botros, J. F. Stoddart. Mechanical Bond Formation by Radical Templation. Angew. Chem. Int. Ed. 2010, 49, 8260.

Angewandte Chemie Very Important Paper.

4.  C.-H. Sue, S. Basu, A. C. Fahrenbach, A. K. Shveyd, S. K. Dey, Y. Y. Botros, J. F. Stoddart. Enabling Tetracationic Cyclophane Production by Trading Templates. Chem. Sci. 2010, 1, 119.

3.  A. Trabolsi, A. C. Fahrenbach, A. I. Share, S. K. Dey, D. C. Friedman, S. Basu, T. B. Gasa, N. M. Khashab, S. Saha, I. Aprahamian, H. A. Khatib, A. H. Flood, J. F. Stoddart. A Tristable [2]Pseudo[2]rotaxane. Chem. Commun. 2010, 46, 871.

2.  A. Trabolsi, N. Khashab, A. C. Fahrenbach, D. C. Friedman, M. T. Colvin, K. Cotí, D. Benítez, E. Tkatchouk, J.-C. Olsen, M. E. Belowich, R. Carmielli, H. A. Khatib, W. A. Goddard III, M. R. Wasielewski, J. F. Stoddart. Radically Enhanced Molecular Recognition. Nature Chem. 2010, 2, 42.

Highlighted in Nature Chemistry News and Views.
L. Anderson. Molecular machines: Radical attraction of like charges. Nature Chem. January 2010.

2009

1.  K. A. McNitt, K. Parimal, A. I. Share, A. C. Fahrenbach, E. H. Witlicki, M. Pink, D. K. Bediako, C. L. Plaisier, N. Le, L. P. Heeringa, D. A. Vander Griend, A. H. Flood. Reduction of a Redox-Active Ligand Drives Switching in a Cu(I) Pseudorotaxane by a Bimolecular Mechanism. J. Am. Chem. Soc. 2009, 131, 1305.